Phthalide Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 87-41-2 |
| Product name | Phthalide |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeIndustrial GradeCosmetic GradeFood Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Phthalide
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Phthalide Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Phthalide
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of antibiotic intermediates | Phthalide undergoes condensation with amines to form amide intermediates, used in the synthesis of antibiotics such as chloramphenicol |
| Fine Fragrances | Ingredient in perfumes and cosmetic fragrances | Phthalide’s aromatic odor is incorporated into fragrance formulations via perfumery compounding to enhance olfactory complexity |
| Pesticides | Intermediate for insecticides and fungicides | Phthalide is converted into biologically active pesticide precursors through organic synthesis reactions such as halogenation and alkylation |
| Organic Synthesis | General-purpose organic synthesis intermediate | Used in nucleophilic substitution and cyclization reactions to construct complex molecular frameworks, including polycyclic compounds |
| Polymers & Materials | Plastic and resin modifier | Acts as a functional monomer or crosslinker in polymerization to improve thermal stability and mechanical properties of polymeric materials |
Manufacturing Quality Control of Phthalide
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Assay | High-Performance Liquid Chromatography (HPLC) | Uses a C18 reversed-phase column with methanol-water or acetonitrile-water as the mobile phase under gradient or isocratic elution. Detection is performed using a UV detector (e.g., 254 nm), and phenolphthalein content is quantified via external or internal standard methods, offering high resolution and accuracy. |
| Impurity Analysis | High-Performance Liquid Chromatography (HPLC) | HPLC is used with optimized chromatographic conditions to effectively separate phenolphthalein from related impurities (such as degradation products or synthesis intermediates). Impurity levels are calculated based on peak areas, meeting pharmacopoeial requirements for purity. |
| Residual Solvent Test | Gas Chromatography (GC) | Employs headspace or direct solution injection, using a capillary column (e.g., DB-624) and an FID detector to detect residual organic solvents (e.g., methanol, ethanol, acetone, dichloromethane) that may remain from the manufacturing process, in compliance with ICH Q3C guidelines. |
| Moisture Content | Karl Fischer Titration | Determines trace moisture content in phenolphthalein active pharmaceutical ingredient by measuring the quantitative reaction of iodine and sulfur dioxide with water in an anhydrous environment, using coulometric or volumetric titration for precise control. |
| Crystal Form Analysis | X-Ray Powder Diffraction (XRPD) | Analyzes the crystal structure of phenolphthalein based on characteristic peak positions and intensities in the X-ray diffraction pattern, used to identify polymorphic forms and ensure batch-to-batch consistency, particularly important for solid drug substance quality control. |
| Melting Point | Capillary Melting Point Method | The sample is packed into a capillary tube and heated gradually in a melting point apparatus to observe initial and complete melting temperatures. This test provides a preliminary assessment of purity and identity, with the melting point typically around 68–70°C. |
| Infrared Identification | Fourier Transform Infrared Spectroscopy (FT-IR) | Infrared absorption spectra are obtained by pressing the phenolphthalein sample with potassium bromide or using ATR technology. Characteristic functional group absorptions (e.g., C=O stretching vibration at ~1750 cm⁻¹) are compared with reference spectra for qualitative identification. |
Technical Specifications of Phthalide
| Test Item | Specification |
|---|---|
| Appearance | White to almost white crystalline powder |
| Purity | >=98.5% (by LC-MS) |
| Melting Point | 70.0 - 72.0 °C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.3% |
| Identification (NMR) | Consistent with reference standard |
| Identification (IR) | Consistent with reference standard |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Phthalide
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Phthalide
Packaging of Phthalide
Industrial Phthalide Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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