(4R,5S)-5-[3,5-Bis(triflu... Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 875444-10-3 |
| Product name | (4R,5S)-5-[3,5-Bis(triflu... |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (4R,5S)-5-[3,5-Bis(triflu...
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (4R,5S)-5-[3,5-Bis(triflu... Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (4R,5S)-5-[3,5-Bis(triflu...
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral auxiliary for asymmetric synthesis, serving as a chiral controller to construct stereocenters | Used as a recyclable chiral oxazolidinone-based auxiliary (Evans auxiliary derivative) in asymmetric alkylation, allylation, and Diels–Alder reactions of substrates such as aldehydes, ketones, and silyl enol ethers; removed via hydrolysis or amine cleavage after reaction |
Manufacturing Quality Control of (4R,5S)-5-[3,5-Bis(triflu...
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at ~220–254 nm, comparing peak area to a certified reference standard. |
| Chiral Purity | (S,S)- vs (R,R)-Diastereomer Ratio | Chiral HPLC |
| Residual Solvents | GC-FID | Detects and quantifies volatile organic solvents (e.g., ethyl acetate, toluene, methanol) by gas chromatography with flame ionization detection against internal standard calibration. |
| Heavy Metals | ICP-MS | Measures trace metal contaminants (e.g., Pb, Cd, Ni, Pd) after acid digestion via inductively coupled plasma mass spectrometry with isotope dilution or external calibration. |
| Water Content | Karl Fischer Titration (Coulometric) | Determines trace water content electrochemically by iodine generation and stoichiometric reaction with water in anhydrous methanol-based reagent. |
| Residue on Ignition | Gravimetric Analysis | Measures non-volatile inorganic residue after controlled ashing at 700–800 °C; expressed as weight percent of original sample. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry or wet dispersed powder to determine volumetric particle size distribution based on Mie scattering theory. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated digital apparatus per USP <741>. |
| Organic Impurities (Related Substances) | HPLC-UV/DAD | Identifies and quantifies structurally related degradants and synthesis intermediates using gradient HPLC with diode array detection and reference standards. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | Measures hydrogen ion activity in a defined suspension (e.g., 1% w/v in water) using calibrated pH electrode per EP 2.2.3. |
| Bulk Density | ASTM D1895 Method A | Determines mass per unit volume of freely settled powder using standardized graduated cylinder and balance per ASTM specification. |
| Loss on Drying | Thermogravimetric Analysis (TGA) | Quantifies volatile content (e.g., solvates, moisture) by measuring mass loss under controlled heating (e.g., 105 °C, 2 h) in nitrogen atmosphere. |
| Optical Rotation | [α]D | Measures specific rotation at sodium D-line (589 nm) using polarimeter; confirms chiral integrity and batch-to-batch consistency per pharmacopeial methods. |
Technical Specifications of (4R,5S)-5-[3,5-Bis(triflu...
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Melting Point | 142-146°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Optical Rotation | +28.5° to +31.5° (c=1, in CHCl3) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (4R,5S)-5-[3,5-Bis(triflu...
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of (4R,5S)-5-[3,5-Bis(triflu...
Industrial (4R,5S)-5-[3,5-Bis(triflu... Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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