BOC-L-LEUCINE N,O-DIMETHYLHYDROXAMIDE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 87694-52-8 |
| Product name | BOC-L-LEUCINE N,O-DIMETHYLHYDROXAMIDE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for BOC-L-LEUCINE N,O-DIMETHYLHYDROXAMIDE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk BOC-L-LEUCINE N,O-DIMETHYLHYDROXAMIDE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of BOC-L-LEUCINE N,O-DIMETHYLHYDROXAMIDE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Chiral β-amino acid derivatives used in the synthesis of proteasome inhibitors (e.g., carfilzomib analogs) and peptide-based drugs | Used as chiral building blocks in coupling reactions to introduce (S)-configured β-amino acid side chains during solid-phase or solution-phase peptide synthesis; the BOC protecting group is cleaved under acidic conditions, and the N-methoxy-N-methylamide moiety enhances stability and coupling efficiency as an active ester precursor |
Manufacturing Quality Control of BOC-L-LEUCINE N,O-DIMETHYLHYDROXAMIDE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 210-220 nm based on peak area response against reference standard. |
| Chiral Purity | (R,S)-HPLC or Chiral SFC | Measures enantiomeric excess by separation on chiral stationary phase with UV detection, comparing retention times and peak areas of (S) and (R) enantiomers. |
| Residual Solvents | GC-FID | Detects and quantifies volatile organic solvents (e.g., THF, toluene, MeOH) using gas chromatography with flame ionization detection against calibrated standards. |
| Water Content | Karl Fischer Titration | Determines water content via coulometric or volumetric titration using iodine-based redox reaction specific for water. |
| Heavy Metals | ICP-MS | Quantifies trace metal impurities (e.g., Pd, Ni, Fe) after acid digestion by measuring elemental mass-to-charge ratios with high sensitivity and multi-element capability. |
| Residual BOC Reagent | GC-FID or HPLC-UV | Detects di-tert-butyl dicarbonate (Boc2O) or tert-butanol by GC-FID or HPLC-UV based on retention time and calibration curve. |
| Related Substances | HPLC-UV | Identifies and quantifies structurally related impurities (e.g., deprotected amine, hydrolyzed acid, N-methoxy isomer) using gradient HPLC with UV detection. |
| Acid Value | Acid-Base Titration | Measures free carboxylic acid impurities by titration with standardized NaOH solution using phenolphthalein or potentiometric endpoint detection. |
| Residual Palladium | ICP-OES | Quantifies palladium catalyst residues after microwave-assisted acid digestion using optical emission from excited Pd atoms at characteristic wavelengths. |
| Appearance | Visual Inspection | Assesses physical state, color, and clarity of solid or solution against established visual standards under controlled lighting conditions. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range at which solid transitions to liquid using calibrated capillary apparatus per USP <741>. |
| Particle Size Distribution | Laser Diffraction | Measures particle size distribution in dry powder form by analyzing angular scattering pattern of laser beam passing through dispersed sample. |
Technical Specifications of BOC-L-LEUCINE N,O-DIMETHYLHYDROXAMIDE
| Test Item | Specification |
|---|---|
| Appearance | Colorless solid |
| Purity | >=99.0% (GC-MS) |
| Optical Rotation | -18.5° ± 1.0° (c=1, in CHCl3) |
| Total Impurities | <=1.0% (GC-MS) |
| Single Impurity | <=0.5% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Melting Point | 72–76°C |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of BOC-L-LEUCINE N,O-DIMETHYLHYDROXAMIDE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of BOC-L-LEUCINE N,O-DIMETHYLHYDROXAMIDE
Safety Information of BOC-L-LEUCINE N,O-DIMETHYLHYDROXAMIDE
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of BOC-L-LEUCINE N,O-DIMETHYLHYDROXAMIDE
Industrial BOC-L-LEUCINE N,O-DIMETHYLHYDROXAMIDE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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