(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 877397-71-2 |
| Product name | (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 877397-71-2
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 877397-71-2 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 877397-71-2
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | As a non-receptor tyrosine kinase c-Met inhibitor for targeted drug development in cancer treatment (e.g., lung cancer, gastric cancer) | Chemical synthesis and biological activity screening |
| Pharmaceuticals | Intermediate or active pharmaceutical ingredient (API) in the preparation of anticancer agents (e.g., cabozantinib) | Organic synthesis and crystallization-based purification |
| Pharmaceutical Research | Small-molecule inhibitor used in preclinical studies to investigate kinase signaling pathway mechanisms | In vitro enzyme activity assays and cell-based assays |
Manufacturing Quality Control of 877397-71-2
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 254 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time relative to reference standards or threshold reporting. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify volatile organic solvents (e.g., methanol, acetone, ethyl acetate) against calibrated standards. |
| Water Content | Karl Fischer Titration | Electrochemical titration using iodine generation in pyridine-free reagent; water reacts stoichiometrically with iodine and sulfur dioxide in methanol medium. |
| Heavy Metals | ICP-MS | Multi-element detection of toxic metals (Pb, Cd, Hg, As) after acid digestion, using isotopic mass spectrometry for sub-ppq sensitivity. |
| Chloride Content | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column with suppressed conductivity detection. |
| Optical Rotation | [alpha]D Measurement | Measurement of specific rotation using sodium D-line light (589 nm) in solution; confirms chiral integrity of the (1R)-configured center. |
| Residue on Ignition | Gravimetric Analysis | Heating sample at 700-800 C to constant weight; residue mass reflects inorganic ash content. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity versus angle to determine volume-based particle size distribution in suspension. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | Direct measurement using calibrated glass electrode in saturated aqueous suspension (1% w/v). |
| Melting Point | Capillary Melting Point Apparatus | Thermal analysis of solid phase transition observed visually or via automated optical detection under controlled heating rate. |
| Microbial Limits | Membrane Filtration and Culture | Enumeration of aerobic microorganisms and absence testing for specified pathogens (e.g., E. coli, S. aureus) per pharmacopeial methods. |
Technical Specifications of 877397-71-2
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 124–128°C |
| Optical Rotation | -185 to -175° (c=1, in methanol) |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 877397-71-2
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 877397-71-2
Packaging of 877397-71-2
Industrial 877397-71-2 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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