(S)-((2-Guanidino-4-thiazolyl)methylisothiourea dihydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 88046-01-9 |
| Product name | (S)-((2-Guanidino-4-thiazolyl)methylisothiourea dihydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 88046-01-9
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 88046-01-9 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 88046-01-9
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Key intermediate for famotidine | Used to synthesize the famotidine side chain; the thiazole ring is constructed via reaction with reagents such as 3-chloropropionitrile |
| Pharmaceutical Chemicals | Chiral building block for drug synthesis | Serves as a chiral guanidino source for constructing sulfur-containing heterocyclic compounds with defined stereochemistry |
| Organic Synthesis | Selective guanylation reagent | Serves as a guanidino-functional group donor in organic synthesis reactions for preparing thiazole derivatives |
Manufacturing Quality Control of 88046-01-9
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at ~210 nm, comparing peak area against a certified reference standard. |
| Chiral Purity (Enantiomeric Excess) | Chiral HPLC | Separation of (S)- and (R)-enantiomers on a chiral stationary phase; enantiomeric excess calculated from peak area ratio. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., methanol, acetone, DMF) based on calibrated response factors. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent; water reacts stoichiometrically with iodine in pyridine/methanol medium. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Multi-element quantification after acid digestion; detection based on mass-to-charge ratio of metal ions with high sensitivity and selectivity. |
| Chloride Impurity | Ion Chromatography (IC) | Separation of chloride anion on anion-exchange column with suppressed conductivity detection; quantified via external calibration. |
| Related Substances | HPLC-UV (Forced Degradation Study) | Detection and quantification of structurally related impurities (e.g., hydrolysis/degradation products) under stressed conditions (acid, base, oxidation, heat, light). |
| pH (1% w/v aqueous solution) | Potentiometric pH Measurement | Determination using calibrated glass electrode in aqueous suspension; reflects protonation state and residual acid content. |
| Residue on Ignition (Sulfated Ash) | Gravimetric Analysis | Ignition at 700–800 °C followed by weighing of inorganic residue; indicates inorganic salt contaminants or metal catalysts. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity vs. scattering angle to determine volumetric particle size distribution in dispersed solid sample. |
| Microbial Contamination | Membrane Filtration & Plate Count | Enumeration of aerobic mesophilic microorganisms following filtration, membrane transfer to agar media, and incubation per Ph. Eur./USP microbiological guidelines. |
| Identity Confirmation | FT-IR Spectroscopy | Comparison of sample infrared absorption spectrum with reference standard; verification based on characteristic functional group bands (e.g., guanidinium, thiazole, isothiourea). |
Technical Specifications of 88046-01-9
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 220-225°C (decomposes) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Optical Rotation | +15.0 to +17.0° (c=1, 1M HCl) |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 88046-01-9
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of 88046-01-9
Industrial 88046-01-9 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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