(S)-N-Boc-piperidine-3-carboxylate methyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 88466-76-6 |
| Product name | (S)-N-Boc-piperidine-3-carboxylate methyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Material GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (S)-N-Boc-piperidine-3-carboxylate methyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-N-Boc-piperidine-3-carboxylate methyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-N-Boc-piperidine-3-carboxylate methyl ester
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for synthesizing chiral drugs, used to construct bioactive molecules containing a piperidine moiety | Prepared via asymmetric synthesis or chiral resolution; commonly employed in synthetic routes for peptides, antipsychotics, and anticancer agents |
| Organic Synthesis | Used as a chiral auxiliary or protecting group in the construction of complex molecules | Nitrogen atom protected with Boc (tert-butoxycarbonyl); methyl ester group convertible to carboxylic acid or amide to facilitate subsequent functional group transformations |
| Advanced Chemicals R&D | Critical intermediate in lead compound screening and structural optimization for new drug discovery | Introduced into target molecules via coupling reactions, reductive amination, or cyclization to modulate specific biological activity |
Manufacturing Quality Control of (S)-N-Boc-piperidine-3-carboxylate methyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reverse-phase HPLC with UV detection at 210-220 nm, calibrated against reference standard. |
| Chiral Purity | Chiral HPLC | Separation of (R)- and (S)-enantiomers on a chiral stationary phase; enantiomeric excess calculated from peak areas. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., methanol, toluene, ethyl acetate) per ICH Q3C. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (Pb, Cd, Hg, As, Ni) after acid digestion and dilution. |
| Residual Palladium | ICP-MS | Specific quantification of Pd residues from catalytic hydrogenation steps using isotope-dilution or external calibration. |
| Acid Value | Acid-Base Titration | Titration with standardized NaOH solution using phenolphthalein indicator to determine free carboxylic acid impurities. |
| Optical Rotation | [alpha]D Measurement | Measurement of specific rotation using sodium D-line light source to confirm chiral integrity and identity. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against established reference standards under controlled lighting. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range over which solid transitions to liquid, indicating purity and identity. |
| Residual Boc Protecting Group | 1H NMR | Qualitative/quantitative assessment of tert-butoxycarbonyl group integrity via characteristic t-butyl proton signals (~1.4 ppm). |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., de-Boc, hydrolyzed ester, diastereomers) using gradient HPLC. |
Technical Specifications of (S)-N-Boc-piperidine-3-carboxylate methyl ester
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Optical Rotation | -15.0° to -18.0° (c=1, in CHCl3) |
| Melting Point | 52°C to 56°C |
| Identification (NMR) | Conforms to reference standard |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (S)-N-Boc-piperidine-3-carboxylate methyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (S)-N-Boc-piperidine-3-carboxylate methyl ester
Safety Information of (S)-N-Boc-piperidine-3-carboxylate methyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (S)-N-Boc-piperidine-3-carboxylate methyl ester
Industrial (S)-N-Boc-piperidine-3-carboxylate methyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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