L-1-Boc-Nipecotic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 88495-54-9 |
| Product name | L-1-Boc-Nipecotic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for L-1-Boc-Nipecotic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk L-1-Boc-Nipecotic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of L-1-Boc-Nipecotic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediates for synthesizing piperidine-containing drug molecules (e.g., antidepressants, analgesics) | Boc deprotection under acidic conditions (e.g., TFA/DCM) in inert solvents (e.g., THF, DCM), followed by coupling reactions to construct active pharmaceutical ingredients |
| Pharmaceutical R&D | Chiral building blocks for constructing small-molecule compound libraries targeting G protein-coupled receptors (GPCRs) | Introduction of specific substituents via amidation, reductive amination, or other functionalization after asymmetric synthesis or chiral resolution, for structure–activity relationship (SAR) studies |
| Fine Chemicals | Chiral ligand precursors for catalysts | Functional group transformations to prepare (S)-piperidine-containing chiral phosphine ligands or N-heterocyclic carbene precursors for asymmetric catalysis |
Manufacturing Quality Control of L-1-Boc-Nipecotic acid
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210 nm, comparing peak area to a certified reference standard. |
| Chiral Purity | Chiral HPLC | Enantiomeric excess assessment using a chiral stationary phase and UV detection, resolving (S)-enantiomer from potential (R)-impurity. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents (e.g., THF, DMF, ethyl acetate) by gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration measuring water via iodine-sulfur dioxide reaction in pyridine/methanol medium. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification (e.g., Pb, Cd, Ni, Fe) after acid digestion, using inductively coupled plasma mass spectrometry. |
| Residual Palladium | ICP-OES | Quantification of palladium residues (from catalytic synthesis) by inductively coupled plasma optical emission spectroscopy. |
| Acid Value | Acid-Base Titration | Neutralization of free carboxylic acid groups with standardized NaOH solution using phenolphthalein indicator. |
| Residual Boc Protecting Group | 1H NMR | Semi-quantitative assessment of tert-butoxycarbonyl group integrity and decomposition products via proton nuclear magnetic resonance. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement using controlled heating and visual observation of solid-to-liquid phase change. |
| Appearance | Visual Inspection | Assessment of physical state, color, and presence of foreign particles under controlled white light and against standard references. |
| Particle Size Distribution | Laser Diffraction | Determination of size distribution profile based on angular scattering intensity of laser light passing through dispersed sample. |
| Microbial Contamination | Membrane Filtration | Quantitative enumeration of aerobic microorganisms following filtration, membrane transfer to culture media, and incubation. |
Technical Specifications of L-1-Boc-Nipecotic acid
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (GC-MS) |
| Optical Rotation | +56.0 to +58.0° (c=1, in CHCl3) |
| Melting Point | 72.0 to 76.0°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of L-1-Boc-Nipecotic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of L-1-Boc-Nipecotic acid
Packaging of L-1-Boc-Nipecotic acid
Industrial L-1-Boc-Nipecotic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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