6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 885271-72-7 |
| Product name | 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Serves as a key intermediate in the synthesis of Bruton’s tyrosine kinase (BTK) inhibitors, such as zanubrutinib and its derivatives | Constructs the drug molecule scaffold via condensation between the 3-formyl group of the indazole ring and amine compounds |
| Pharmaceutical Chemicals | Used in the production of antitumor agents targeting protein kinases | Incorporates the 6-bromoindazole moiety into target drug molecules via coupling reactions or functional group transformations |
| Organic Synthesis | Builds indazole-fused heterocyclic compounds | The aldehyde group participates in cyclization reactions; the bromine atom serves as a reactive site for further derivatization (e.g., Suzuki coupling) |
| Research Reagents | Prepares compounds for drug screening and biological activity assessment | Enables combinatorial chemical synthesis based on structural diversity |
Manufacturing Quality Control of 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at ~254 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV or UPLC-UV | Separates and quantifies impurities (e.g., starting materials, isomers, dehalogenated by-products) using gradient elution and UV detection. |
| Residual Solvents | GC-FID | Detects and quantifies volatile organic solvents (e.g., DMF, THF, ethyl acetate) via headspace GC with flame ionization detection against calibrated standards. |
| Water Content | Karl Fischer Titration (Coulometric) | Determines trace water content electrochemically by iodine generation and stoichiometric reaction with water in anhydrous medium. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pd, Ni, Fe, Pb) after acid digestion, using mass spectrometry for ultra-trace multi-element detection. |
| Residual Palladium | ICP-OES | Measures palladium catalyst residue post-hydrogenation/coupling, using plasma excitation and optical emission detection at characteristic wavelengths. |
| Melting Point | Capillary Melting Point Apparatus | Determines thermal transition range via controlled heating of a capillary sample, indicating crystallinity and identity. |
| Appearance | Visual Inspection | Assesses physical state, color, and presence of foreign particles under controlled white light against defined pharmacopeial criteria. |
| Chloride Impurity | Ion Chromatography (IC) | Separates and quantifies chloride ions (from HCl salt formation or hydrolysis) using suppressed conductivity detection. |
| Particle Size Distribution | Laser Diffraction | Measures size distribution of solid particles in suspension via angular scattering pattern analysis of laser light. |
| Loss on Drying (LOD) | Gravimetric Thermogravimetry | Determines volatile content by measuring mass loss upon controlled heating (e.g., 105 °C, 2 h) under inert atmosphere. |
| Optical Rotation | Polarimetry | Measures specific rotation using sodium D-line light to confirm chiral integrity if applicable (though compound is achiral, used for batch consistency). |
Technical Specifications of 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE
| Test Item | Specification |
|---|---|
| Appearance | Brown solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 178–182°C |
| Identification (NMR) | Conforms to reference standard |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE
Safety Information of 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE
Industrial 6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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