Bardoxolone Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 890707-28-5 |
| Product name | Bardoxolone |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Bardoxolone
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Bardoxolone Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Bardoxolone
| Industry | Application | Process |
|---|---|---|
| Pesticides | Herbicide intermediate | Used in the synthesis of benzamide herbicides (e.g., analogues of florasulam), involving amidation, cyclization, and oxidation to construct the triazolopyrimidine scaffold |
| Pharmaceuticals | Potential drug synthesis intermediate | Employed as a structural modification unit in the molecular construction of anti-inflammatory or antitumor candidate compounds; commonly applied in Suzuki coupling or Pd-catalyzed C–N bond formation reactions |
| Chemicals | Organic synthesis intermediate | Used to prepare functional dyes, fluorescent probes, and polymer monomers; typical processes include diazotization-iodination, halogen exchange, or transition metal-catalyzed cross-coupling |
Manufacturing Quality Control of Bardoxolone
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Assay (Main Component Purity) | High-Performance Liquid Chromatography (HPLC) | Uses a C18 column with gradient elution of water-acetonitrile or methanol as the mobile phase. The analyte is detected by a UV detector (254 nm or 280 nm), and quantified via external or internal standard method. Offers high accuracy and good reproducibility. |
| Impurity Profile (Related Substances) | High-Performance Liquid Chromatography (HPLC) | Employs a gradient elution program to detect potential impurities such as residual starting materials, degradation products (e.g., deamidation, oxidation, hydrolysis), and isomers. Detection wavelength is typically set at the maximum absorption wavelength of the main component. Impurity limits are calculated (e.g., ≤0.1%). |
| Residual Solvents | Gas Chromatography (GC) | Uses headspace or direct injection with an FID detector to determine residual solvents (e.g., methanol, ethanol, dichloromethane) according to ICH Q3C guidelines, ensuring compliance with pharmaceutical-grade limits. |
| Water Content | Karl Fischer Titration | Measures trace water content via a quantitative reaction involving iodine, sulfur dioxide, pyridine, and methanol. Suitable for solid raw materials with ppm-level precision, meeting pharmacopeial requirements (e.g., ≤0.5%). |
| Melting Point | Melting Point Apparatus | Determines the melting temperature range using a digital melting point apparatus. Compared with literature values (typical range: 140–150°C) for preliminary identification and purity assessment. |
| Chlorine Content (Elemental Analysis) | Elemental Analyzer (EA) or Ion Chromatography (IC) | EA method involves high-temperature combustion followed by determination of chlorine percentage; IC method measures chloride ion concentration after sample hydrolysis. Used to verify whether chlorine content matches theoretical value (theoretical Cl ≈ 18.5%). |
| pH Value (Aqueous Solution) | pH Meter | Sample is dissolved in water to form a saturated or specified concentration solution, and pH is measured using a calibrated pH meter. Assesses acidity/basicity and helps evaluate stability or process impact (typically neutral to weakly acidic). |
| Particle Size Distribution (if powder formulation) | Laser Diffraction or Microscopy | If used as a raw material for solid dosage forms, particle size distribution is measured to ensure proper flowability and solubility for manufacturing processes (e.g., D90 < 50 μm). |
| UV-Visible Absorption Spectroscopy (UV-Vis) | UV Spectrophotometry | Scans absorption spectrum in the 200–400 nm range to identify characteristic peaks (e.g., λmax ≈ 260–280 nm), used for qualitative identification and auxiliary quantitative analysis. |
| Nuclear Magnetic Resonance (¹H NMR / ¹³C NMR) | Nuclear Magnetic Resonance Spectroscopy | Using DMSO-d6 or CDCl3 as solvent, confirms molecular structure through ¹H and ¹³C spectra. Verifies signal positions and integration ratios of functional groups such as amino, methyl, and chlorophenyl rings, used for structural confirmation and impurity identification. |
| Infrared Spectroscopy (FT-IR) | Fourier Transform Infrared Spectroscopy | Measures characteristic functional group absorption bands (e.g., NH₂ stretching vibration ~3400 cm⁻¹, amide I band C=O ~1660 cm⁻¹, C-Cl ~750 cm⁻¹), used for structural identification and batch-to-batch consistency comparison. |
Technical Specifications of Bardoxolone
| Test Item | Specification |
|---|---|
| Appearance | Brown solid |
| Purity | >=98.0% (by LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142–146°C |
| Identification (NMR) | Conforms to reference standard |
| Identification (IR) | Conforms to reference standard |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Bardoxolone
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Bardoxolone
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Industrial Bardoxolone Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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